Annotation Detail
Information
- Associated Genes
- PIK3CG
- Associated Variants
-
PIK3CG MUTATION
PIK3CG MUTATION - Associated Disease
- colorectal carcinoma
- Source Database
- DisGeNET
- Description
- Inhibitors against KRAS signaling mediators, namely, PI3K (phosphatidylinositol 3-kinase) and mTOR (mechanistic target of rapamycin), have limited clinical efficacy as single agents in KRAS-mutant colorectal cancer (CRC).
- Pubmed
- 25389372
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0119434423715333
Drugs