Annotation Detail
Information
- Associated Genes
- HTR3A
- Associated Variants
-
HTR3B p.Tyr129Ser (p.Y129S)
(
ENST00000537778.5,
ENST00000260191.8 )
HTR3B p.Tyr129Ser (p.Y129S) ( ENST00000260191.8, ENST00000537778.5 ) - Associated Disease
- heroin dependence
- Source Database
- DisGeNET
- Description
- In this study, 360 treatment-seeking African American male patients with single and comorbid DSM-IV lifetime diagnoses of alcohol, cocaine and heroin dependence and 187 African American male controls were genotyped for the triallelic 5-HTTLPR functional polymorphism in the 5-HT transporter gene (SLC6A4) and 16 haplotype-tagging single-nucleotide polymorphisms (SNPs) across HTR3B (including the functional rs1176744 Tyr129Ser) and HTR3A, genes encoding 5-HT3 receptors.
- Pubmed
- 20838391
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2011
Drugs