Annotation Detail
Information
- Associated Genes
- ITGAM
- Associated Variants
-
ITGAM p.Arg77His (p.R77H)
(
ENST00000648685.1,
ENST00000544665.9 )
rs3093030
ITGAM p.Arg77His (p.R77H) ( ENST00000544665.9, ENST00000648685.1 )
rs3093030 - Associated Disease
- Lupus Erythematosus, Systemic
- Source Database
- DisGeNET
- Description
- The A-allele of ICAM1-ICAM4-ICAM5 rs3093030, associated with elevated plasma levels of soluble ICAM1, and the A-allele of ITGAM rs1143679 showed the strongest association with increased SLE susceptibility in each of the ancestry populations and the trans-ancestry meta-analysis (OR(meta)=1.16, 95% CI 1.11 to 1.22; p=4.88×10(-10) and OR(meta)=1.67, 95% CI 1.55 to 1.79; p=3.32×10(-46), respectively).
- Pubmed
- 22523428
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.27872910640394
- Year of publication
- 2012
Drugs