Annotation Detail
Information
- Associated Genes
- IL10
- Associated Variants
-
PTGS2 c.*427T>C
(
ENST00000680451.1,
ENST00000367468.10 )
NR_125801.1(PACERR):n.536C>G
rs689466
rs3024505
IL19 c.-149+1984T>G ( ENST00000659642.2, ENST00000659997.3, ENST00000656872.2, ENST00000659065.2, ENST00000664374.2 )
IL1B c.-118C>T
NC_000002.12:g.112838252C>G
rs4848306
PTGS2 c.*427T>C ( ENST00000367468.10, ENST00000680451.1 )
NR_125801.1(PACERR):n.536C>G
rs689466
rs3024505
IL19 c.-149+1984T>G ( ENST00000659065.2, ENST00000659642.2, ENST00000664374.2, ENST00000656872.2, ENST00000659997.3 )
IL1B c.-118C>T
NC_000002.12:g.112838252C>G
rs4848306 - Associated Disease
- colorectal cancer
- Source Database
- DisGeNET
- Description
- The polymorphisms IL10 C-592A (rs1800872), C-rs3024505-T, IL1b C-3737T (rs4848306), G-1464C (rs1143623), T-31C (rs1143627) and PTGS2 (encoding COX-2) A-1195G (rs689466), G-765C (rs20417), and T8473C (rs5275) were assessed in relation to risk of colorectal cancer (CRC) and interaction with diet (red meat, fish, fibre, cereals, fruit and vegetables) and lifestyle (non-steroid-anti-inflammatory drug use and smoking status) was assessed in a nested case-cohort study of nine hundred and seventy CRC cases and 1789 randomly selected participants from a prospective study of 57,053 persons.
- Pubmed
- 24194923
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0128013752494925
- Year of publication
- 2013
Drugs