Annotation Detail
Information
- Associated Genes
- DNMT3B
- Associated Variants
-
FTO c.46-23525T>A
(
ENST00000636491.1,
ENST00000636218.1,
ENST00000471389.6,
ENST00000637969.1,
ENST00000637001.1 )
LEPR p.Gln223Arg (p.Q223R) ( ENST00000344610.12, ENST00000371058.1, ENST00000371060.7, ENST00000616738.4, ENST00000371059.7, ENST00000349533.11 )
DNMT3B c.1490+164G>T ( ENST00000201963.3, ENST00000328111.6, ENST00000348286.6, ENST00000353855.6, ENST00000443239.7, ENST00000456297.6, ENST00000696232.1, ENST00000696239.1 )
FTO c.46-23525T>A ( ENST00000471389.6, ENST00000636218.1, ENST00000636491.1, ENST00000637001.1, ENST00000637969.1 )
LEPR p.Gln223Arg (p.Q223R) ( ENST00000344610.12, ENST00000349533.11, ENST00000371058.1, ENST00000371059.7, ENST00000371060.7, ENST00000616738.4 )
DNMT3B c.1490+164G>T ( ENST00000201963.3, ENST00000328111.6, ENST00000348286.6, ENST00000353855.6, ENST00000443239.7, ENST00000456297.6, ENST00000696232.1, ENST00000696239.1 ) - Associated Disease
- Hunger
- Source Database
- DisGeNET
- Description
- Individuals with a low postprandial decrease in hunger were overrepresented among TA/AA (dominant), CC/CA (recessive), and AG/GG (dominant) carriers in rs9939609 (FTO), rs992472 (DNMT3B), and rs1137101 (LEPR), respectively (n = 39), compared with TT, AA, and/or AA carriers in these SNPs, respectively (P = 0.00001).
- Pubmed
- 19793853
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2009
Drugs