Annotation Detail

Information
Associated Genes
SNCA
Associated Variants
SNCA p.Glu46Lys (p.E46K) ( ENST00000336904.7, ENST00000345009.8, ENST00000394986.5, ENST00000394989.6, ENST00000394991.8, ENST00000420646.6, ENST00000502987.5, ENST00000505199.5, ENST00000506244.5, ENST00000508895.5, ENST00000611107.1, ENST00000618500.4, ENST00000673718.1, ENST00000673902.1, ENST00000674129.1 )
SNCA p.Glu46Lys (p.E46K) ( ENST00000336904.7, ENST00000345009.8, ENST00000394986.5, ENST00000394989.6, ENST00000394991.8, ENST00000420646.6, ENST00000502987.5, ENST00000505199.5, ENST00000506244.5, ENST00000508895.5, ENST00000611107.1, ENST00000618500.4, ENST00000673718.1, ENST00000673902.1, ENST00000674129.1 )
Associated Disease
Lewy body dementia Autosomal dominant Parkinson disease 1
Source Database
ClinVar
Description
NM_000345.4(SNCA):c.136G>A (p.Glu46Lys) AND multiple conditions
ClinVar Allele ID
29049
ClinVar RefSeq Alternation Syntax
NM_001375285.1:c.136G>A
ClinVar RefSeq Alternation Syntax
NM_001375288.1:c.136G>A
ClinVar RefSeq Alternation Syntax
NR_164674.1:n.214G>A
ClinVar RefSeq Alternation Syntax
NM_001375286.1:c.136G>A
ClinVar RefSeq Alternation Syntax
NM_001375287.1:c.136G>A
ClinVar RefSeq Alternation Syntax
NR_164675.1:n.361G>A
ClinVar RefSeq Alternation Syntax
NM_000345.4:c.136G>A
ClinVar RefSeq Alternation Syntax
NM_001146054.2:c.136G>A
ClinVar RefSeq Alternation Syntax
NR_164676.1:n.434G>A
ClinVar RefSeq Alternation Syntax
NM_007308.3:c.136G>A
ClinVar RefSeq Alternation Syntax
NM_001146055.2:c.136G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-08-04
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002514100
ClinVar Disease
Lewy body dementia
ClinVar Disease
Autosomal dominant Parkinson disease 1
Observed Origin Sample
germline
Drugs