Annotation Detail

Information
Associated Genes
PIK3CA
Associated Variants
PIK3CA p.Asn345Lys (p.N345K) ( ENST00000263967.4, ENST00000643187.1 )
PIK3CA p.Asn345Lys (p.N345K) ( ENST00000263967.4, ENST00000643187.1 )
Associated Disease
Congenital macrodactylia CLAPO syndrome seborrheic keratosis CLOVES syndrome Cowden syndrome 5 hepatocellular carcinoma Neoplasm of ovary epidermal nevus Gastric cancer lung cancer colorectal cancer Familial cancer of breast Megalencephaly-capillary malformation-polymicrogyria syndrome
Source Database
ClinVar
Description
NM_006218.4(PIK3CA):c.1035T>A (p.Asn345Lys) AND multiple conditions
ClinVar Allele ID
362929
ClinVar RefSeq Alternation Syntax
NM_006218.4:c.1035T>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-03-23
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002502454
ClinVar Disease
Lung cancer
ClinVar Disease
Colorectal cancer
ClinVar Disease
Familial cancer of breast
ClinVar Disease
Hepatocellular carcinoma
ClinVar Disease
Epidermal nevus
ClinVar Disease
CLOVES syndrome
ClinVar Disease
Cowden syndrome 5
ClinVar Disease
Congenital macrodactylia
ClinVar Disease
Seborrheic keratosis
ClinVar Disease
Neoplasm of ovary
ClinVar Disease
CLAPO syndrome
ClinVar Disease
Megalencephaly-capillary malformation-polymicrogyria syndrome
ClinVar Disease
Gastric cancer
Observed Origin Sample
unknown
Drugs