Annotation Detail

Information
Associated Genes
MTHFR
Associated Variants
MTHFR p.Ser481= (p.S481=) ( ENST00000376585.6, ENST00000376583.7, ENST00000423400.7, ENST00000641820.1, ENST00000376590.9, ENST00000376592.6, ENST00000641407.1 )
MTHFR p.Ser481= (p.S481=) ( ENST00000376583.7, ENST00000376585.6, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 )
Associated Disease
thrombophilia due to thrombin defect schizophrenia Homocystinuria due to methylene tetrahydrofolate reductase deficiency Neural tube defects, folate-sensitive
Source Database
ClinVar
Description
NM_005957.5(MTHFR):c.1320G>A (p.Ser440=) AND multiple conditions
ClinVar Allele ID
185770
ClinVar RefSeq Alternation Syntax
NM_001330358.2:c.1443G>A
ClinVar RefSeq Alternation Syntax
NM_005957.5:c.1320G>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2021-08-10
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002498831
ClinVar Disease
Thrombophilia due to thrombin defect
ClinVar Disease
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
ClinVar Disease
Neural tube defects, folate-sensitive
ClinVar Disease
Schizophrenia
Observed Origin Sample
unknown
Drugs