Annotation Detail

Information
Associated Genes
ATM
Associated Variants
ATM p.Arg447Ter (p.R447*) ( ENST00000278616.10, ENST00000452508.7, ENST00000531525.3, ENST00000601453.3, ENST00000675843.1, ENST00000713844.1 )
ATM p.Arg447Ter (p.R447*) ( ENST00000278616.10, ENST00000452508.7, ENST00000531525.3, ENST00000601453.3, ENST00000675843.1, ENST00000713844.1 )
Associated Disease
Ataxia-telangiectasia syndrome Breast cancer, susceptibility to
Source Database
ClinVar
Description
NM_000051.4(ATM):c.1339C>T (p.Arg447Ter) AND multiple conditions
ClinVar Allele ID
132794
ClinVar RefSeq Alternation Syntax
NM_001351834.2:c.1339C>T
ClinVar RefSeq Alternation Syntax
NM_000051.4:c.1339C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-10-08
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001258117
ClinVar Disease
Ataxia-telangiectasia syndrome
ClinVar Disease
Breast cancer, susceptibility to
Observed Origin Sample
germline
Drugs