Annotation Detail

Information
Associated Genes
PIK3CA
Associated Variants
PIK3CA p.His1047Tyr (p.H1047Y) ( ENST00000263967.4, ENST00000643187.1 )
PIK3CA p.His1047Tyr (p.H1047Y) ( ENST00000263967.4, ENST00000643187.1 )
Associated Disease
epidermal nevus CLOVES syndrome Neoplasm of ovary Neoplasm of stomach hepatocellular carcinoma Congenital macrodactylia Familial cancer of breast Carcinoma of colon seborrheic keratosis Megalencephaly-capillary malformation-polymicrogyria syndrome Cowden syndrome 5 lung carcinoma CLAPO syndrome
Source Database
ClinVar
Description
NM_006218.4(PIK3CA):c.3139C>T (p.His1047Tyr) AND multiple conditions
ClinVar Allele ID
48304
ClinVar RefSeq Alternation Syntax
NM_006218.4:c.3139C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-10-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000763508
ClinVar Disease
Carcinoma of colon
ClinVar Disease
Neoplasm of stomach
ClinVar Disease
Familial cancer of breast
ClinVar Disease
Hepatocellular carcinoma
ClinVar Disease
Lung carcinoma
ClinVar Disease
Epidermal nevus
ClinVar Disease
CLOVES syndrome
ClinVar Disease
Cowden syndrome 5
ClinVar Disease
Congenital macrodactylia
ClinVar Disease
Seborrheic keratosis
ClinVar Disease
Neoplasm of ovary
ClinVar Disease
CLAPO syndrome
ClinVar Disease
Megalencephaly-capillary malformation-polymicrogyria syndrome
Observed Origin Sample
unknown
Drugs