Annotation Detail

Information
Associated Genes
KRAS
Associated Variants
KRAS c.*12A>T ( ENST00000685328.1, ENST00000256078.10, ENST00000311936.8, ENST00000557334.6, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 )
KRAS c.*12A>T ( ENST00000256078.10, ENST00000311936.8, ENST00000557334.6, ENST00000685328.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 )
Associated Disease
Carcinoma of pancreas autoimmune lymphoproliferative syndrome type 4 Familial cancer of breast acute myeloid leukemia Hereditary diffuse gastric adenocarcinoma lung carcinoma linear nevus sebaceous syndrome cardiofaciocutaneous syndrome 2 Malignant tumor of urinary bladder Noonan syndrome 3 Cerebral arteriovenous malformation
Source Database
ClinVar
Description
NM_004985.5(KRAS):c.458A>T (p.Asp153Val) AND multiple conditions
ClinVar Allele ID
27626
ClinVar RefSeq Alternation Syntax
NM_001369786.1:c.*12A>T
ClinVar RefSeq Alternation Syntax
NM_033360.4:c.*12A>T
ClinVar RefSeq Alternation Syntax
NM_004985.5:c.458A>T
ClinVar RefSeq Alternation Syntax
NM_001369787.1:c.458A>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-10-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000763307
ClinVar Disease
Linear nevus sebaceous syndrome
ClinVar Disease
Malignant tumor of urinary bladder
ClinVar Disease
Carcinoma of pancreas
ClinVar Disease
Cardiofaciocutaneous syndrome 2
ClinVar Disease
Hereditary diffuse gastric adenocarcinoma
ClinVar Disease
Familial cancer of breast
ClinVar Disease
Noonan syndrome 3
ClinVar Disease
Lung carcinoma
ClinVar Disease
Autoimmune lymphoproliferative syndrome type 4
ClinVar Disease
Acute myeloid leukemia
ClinVar Disease
Cerebral arteriovenous malformation
Observed Origin Sample
unknown
Drugs