Annotation Detail

Information
Associated Genes
GLB1
Associated Variants
GLB1 p.Arg148Cys (p.R148C) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
GLB1 p.Arg148Cys (p.R148C) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
Associated Disease
GM1 gangliosidosis type 2 GM1 gangliosidosis type 3 Infantile GM1 gangliosidosis Mucopolysaccharidosis, MPS-IV-B
Source Database
ClinVar
Description
NM_000404.4(GLB1):c.442C>T (p.Arg148Cys) AND multiple conditions
ClinVar Allele ID
98814
ClinVar RefSeq Alternation Syntax
NM_001135602.3:c.246-2688C>T
ClinVar RefSeq Alternation Syntax
NM_001079811.3:c.352C>T
ClinVar RefSeq Alternation Syntax
NM_000404.4:c.442C>T
ClinVar RefSeq Alternation Syntax
NM_001393580.1:c.442C>T
ClinVar RefSeq Alternation Syntax
NM_001317040.2:c.586C>T
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2022-02-23
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000666298
ClinVar Disease
GM1 gangliosidosis type 3
ClinVar Disease
GM1 gangliosidosis type 2
ClinVar Disease
Infantile GM1 gangliosidosis
ClinVar Disease
Mucopolysaccharidosis, MPS-IV-B
Observed Origin Sample
unknown
Drugs