Annotation Detail

Information
Associated Genes
PSEN2
Associated Variants
ENSG00000288674 p.Thr122Pro (p.T122P), PSEN2 p.Thr122Pro (p.T122P) ( ENST00000679088.1, ENST00000472139.2, ENST00000366783.8, ENST00000676945.1, ENST00000677599.1, ENST00000677414.1, ENST00000677880.1, ENST00000626989.3, ENST00000366782.6, ENST00000678320.1, ENST00000422240.6 )
ENSG00000288674 p.Thr122Pro (p.T122P), PSEN2 p.Thr122Pro (p.T122P) ( ENST00000366782.6, ENST00000366783.8, ENST00000422240.6, ENST00000472139.2, ENST00000626989.3, ENST00000676945.1, ENST00000677414.1, ENST00000677599.1, ENST00000677880.1, ENST00000678320.1, ENST00000679088.1 )
Associated Disease
not provided
Source Database
ClinVar
Description
NM_000447.3(PSEN2):c.364A>C (p.Thr122Pro) AND not provided
ClinVar Allele ID
23888
ClinVar RefSeq Alternation Syntax
NM_012486.3:c.364A>C
ClinVar RefSeq Alternation Syntax
NM_000447.3:c.364A>C
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2023-03-01
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000084260
ClinVar Disease
not provided
Observed Origin Sample
germline
Observed Origin Sample
not provided
Drugs