Annotation Detail
Information
- Associated Genes
- IDH1
- Associated Variants
-
IDH1 p.Arg132His (p.R132H)
(
ENST00000345146.7,
ENST00000415913.5,
ENST00000446179.5 )
IDH1 p.Arg132His (p.R132H) ( ENST00000345146.7, ENST00000415913.5, ENST00000446179.5 ) - Associated Disease
- oligodendroglioma
- Source Database
- CIViC Evidence
- Description
- In pre-clinical studies, an IDH1 inhibitor (AG-5198) impaired growth of glioma / anaplastic oligodendroglioma cell lines with IDH1 R132H mutations. A phase I clinical trial of the AG-120 IDH1 inhibitor in IDH1 mutant positive solid tumors, including glioma is currently underway.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/979
- Gene URL
- https://civic.genome.wustl.edu/links/genes/26
- Variant URL
- https://civic.genome.wustl.edu/links/variants/420
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Anaplastic Oligodendroglioma
- Evidence Direction
- Supports
- Drug
- AGI-5198
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23558169
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| AGI-5198 | Sensitivity | true |