Annotation Detail
Information
- Associated Genes
- BRCA1
- Associated Variants
-
BRCA1 EXPRESSION
BRCA1 EXPRESSION - Associated Disease
- malignant mesothelioma
- Source Database
- CIViC Evidence
- Description
- Expression of BRCA1 in 6 mesothelioma cell lines was associated with sensitivity to vinorelbine in functional studies.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/933
- Gene URL
- https://civic.genome.wustl.edu/links/genes/6
- Variant URL
- https://civic.genome.wustl.edu/links/variants/397
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Malignant Mesothelioma
- Evidence Direction
- Supports
- Drug
- Vinorelbine
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 22190288
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Vinorelbine | Sensitivity | true |