Annotation Detail

Information

Associated Genes: TOP1
Associated Variants: TOP1 EXPRESSION
TOP1 EXPRESSION
Associated Disease: ovarian cancer
Source Database: CIViC Evidence
Description: Shorter progression free survival was observed in patients with low expression (IHC) of topoisomerase 1 in 16 patients with relapsed or persistent ovarian or peritoneal carcinoma after treatment with topotecan, cyclophosphamide and carboplatin followed by an autologous hematopoietic stem cell transplant.
Variant Origin: N/A
Variant Origin: N/A
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/910
Gene URL: https://civic.genome.wustl.edu/links/genes/5845
Variant URL: https://civic.genome.wustl.edu/links/variants/384
Rating: 2
Evidence Type: Predictive
Disease: Ovarian Cancer
Evidence Direction: Supports
Drug: Topotecan,Cyclophosphamide,Carboplatin
Evidence Level: B
Clinical Significance: Sensitivity/Response
Pubmed: 19648970

Drugs