Annotation Detail
Information
- Associated Genes
- AURKA
- Associated Variants
-
AURKA OVEREXPRESSION
(
ENST00000395913.7 )
AURKA OVEREXPRESSION ( ENST00000395913.7 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- High levels of Aurora-A expression (retrospectively assessed by IHC in 102 NSCLC patients) predicted poorer overall survival and progression free survival in a population treated with surgery and cisplatin-based chemotherapy. In-vitro data confirmed these results and overexpression or knockdown of AURKA decreased or increased in-vitro sensitivity to cisplatin.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/871
- Gene URL
- https://civic.genome.wustl.edu/links/genes/61
- Variant URL
- https://civic.genome.wustl.edu/links/variants/181
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Cisplatin
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 25082261
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cisplatin | Resitance or Non-Reponse | true |