Annotation Detail
Information
- Associated Genes
- ERBB3
- Associated Variants
-
ERBB3 EXPRESSION
ERBB3 EXPRESSION - Associated Disease
- pancreatic ductal adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- In mice xenografts expressing ERBB3 (HER3) the combination of ERBB2 (HER2) and ERBB3 inhibitors pertuzumab and 9F7-F11enhanced tumor inhibition and the median survival time. Sensitivity to single-agent pertuzumab might also be increased through ERBB3 expression.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/865
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1733
- Variant URL
- https://civic.genome.wustl.edu/links/variants/361
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Pancreatic Ductal Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Pertuzumab,9F7-F11
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25216528
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| 9F7-F11 | Sensitivity | true |
| Pertuzumab | Sensitivity | true |