Annotation Detail
Information
- Associated Genes
- ERBB3
- Associated Variants
-
ERBB3 EXPRESSION
ERBB3 EXPRESSION - Associated Disease
- cancer
- Source Database
- CIViC Evidence
- Description
- The authors conducted an in vivo efficacy study of AV-203 (ERBB3 inhibitory antibody) using a panel of 32 xenograft models representing 12 human cancer types. To identify biomarkers that can predict response to AV-203, the relationship between tumor growth inhibition (TGI) by AV-203 and the expression levels of ERBB3 and NRG1 were evaluated in these tumor models. ERBB3 expression was not predictive of response.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/862
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1733
- Variant URL
- https://civic.genome.wustl.edu/links/variants/361
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Cancer
- Evidence Direction
- Does Not Support
- Drug
- Anti-ErbB3 Monoclonal Antibody AV-203
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25542901
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Anti-ErbB3 Monoclonal Antibody AV-203 | Sensitivity | false |