Annotation Detail
Information
- Associated Genes
- CCND1
- Associated Variants
-
CCND1 AMPLIFICATION
(
ENST00000227507.3 )
CCND1 AMPLIFICATION ( ENST00000227507.3 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- In this retrospective analysis, CCND1 amplification was analyzed in 442 patients. No interaction with treatment was observed.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/858
- Gene URL
- https://civic.genome.wustl.edu/links/genes/8
- Variant URL
- https://civic.genome.wustl.edu/links/variants/18
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Does Not Support
- Drug
- Tamoxifen
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 24367492
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Tamoxifen | Resitance or Non-Reponse | false |