Annotation Detail
Information
- Associated Genes
- CCND1
- Associated Variants
-
CCND1 OVEREXPRESSION
(
ENST00000227507.3 )
CCND1 OVEREXPRESSION ( ENST00000227507.3 ) - Associated Disease
- estrogen-receptor positive breast cancer
- Source Database
- CIViC Evidence
- Description
- The authors performed a tissue microarray analysis of 167 postmenopausal breast cancers that had been randomized to treatment with or without tamoxifen. ER +ve patients with high CCND1 tumor expression did not show any difference in survival between tamoxifen and no treatment.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/856
- Gene URL
- https://civic.genome.wustl.edu/links/genes/8
- Variant URL
- https://civic.genome.wustl.edu/links/variants/20
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Estrogen-receptor Positive Breast Cancer
- Evidence Direction
- Supports
- Drug
- Tamoxifen
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 15138475
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Tamoxifen | Resitance or Non-Reponse | true |