Annotation Detail

Information
Associated Genes
PRPS1
Associated Variants
PRPS1 N144S
PRPS1 N144S
Associated Disease
childhood B-cell acute lymphoblastic leukemia
Source Database
CIViC Evidence
Description
Lentiviral-mediated overexpression of PRPS1 N144S in Reh cells resulted in sensitivity to cytarabine (Ara-C) treatment as indicated by reduced cell viability and IC50 compared to empty vector and wildtype PRPS1 overexpression controls.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/7910
Gene URL
https://civic.genome.wustl.edu/links/genes/4566
Variant URL
https://civic.genome.wustl.edu/links/variants/2923
Rating
2
Evidence Type
Predictive
Disease
Childhood B-cell Acute Lymphoblastic Leukemia
Evidence Direction
Supports
Drug
Cytarabine
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
25962120
Drugs
Drug NameSensitivitySupported
CytarabineSensitivitytrue