Annotation Detail
Information
- Associated Genes
- NRAS
- Associated Variants
-
NRAS Q61
NRAS Q61 - Associated Disease
- thyroid gland follicular carcinoma
- Source Database
- CIViC Evidence
- Description
- Follicular thyroid cancers harboring RAS mutations have limited aggressiveness in the absence of TERT mutations. 2/2 follicular thyroid cancer patients with co-mutations in NRAS (10 Q61R and 1 Q61K) or HRAS (2 Q61R and 1 Q61K) and TERT promoter mutations had persistent or recurrent disease compared to 1/11 patients with only a RAS mutation (100% vs 8%, P=0.03).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/6959
- Gene URL
- https://civic.genome.wustl.edu/links/genes/36
- Variant URL
- https://civic.genome.wustl.edu/links/variants/94
- Rating
- 2
- Evidence Type
- Prognostic
- Disease
- Follicular Thyroid Carcinoma
- Evidence Direction
- Does Not Support
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 25448848
Drugs