Annotation Detail
Information
- Associated Genes
- GSTP1
- Associated Variants
-
GSTP1 DELETION
(
ENST00000398606.10 )
GSTP1 DELETION ( ENST00000398606.10 ) - Associated Disease
- ovarian carcinoma
- Source Database
- CIViC Evidence
- Description
- Stable GSTP1 knockdown in ovarian carcinoma A2780 cell lines showed increased sensitivity to platinum-based chemotherapy drugs carboplatin, cisplatinum, carboplatin, and paclitaxel. For each drug, 3 biological replicates were performed for this study, and effectiveness was evaluated using an MTT assay. There was not a significant difference in sensitivity to other chemotherapy drugs such as gemcitabine, topotecan, and doxorubicin.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/660
- Gene URL
- https://civic.genome.wustl.edu/links/genes/2473
- Variant URL
- https://civic.genome.wustl.edu/links/variants/250
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Ovarian Carcinoma
- Evidence Direction
- Supports
- Drug
- Cisplatin,Carboplatin,Paclitaxel
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25010864
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Carboplatin | Sensitivity | true |
| Cisplatin | Sensitivity | true |
| Paclitaxel | Sensitivity | true |