Annotation Detail
Information
- Associated Genes
- CD274
- Associated Variants
-
CD274 EXPRESSION
CD274 EXPRESSION - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- PD-L1 expression in at least 50% of tumor cells correlated with improved efficacy of pembrolizumab.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/5811
- Gene URL
- https://civic.genome.wustl.edu/links/genes/11335
- Variant URL
- https://civic.genome.wustl.edu/links/variants/276
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Pembrolizumab
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25891174
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Pembrolizumab | Sensitivity | true |