Annotation Detail
Information
- Associated Genes
- MYC
- Associated Variants
-
MYC OVEREXPRESSION
MYC OVEREXPRESSION - Associated Disease
- multiple myeloma
- Source Database
- CIViC Evidence
- Description
- BET inhibition by JQ1 downregulates MYC transcription, followed by genome-wide downregulation of Myc-dependent target genes. In experimental models of multiple myeloma, a Myc-dependent hematologic malignancy, JQ1 produces a potent antiproliferative effect associated with cell-cycle arrest and cellular senescence.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/5505
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3737
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1303
- Rating
- 5
- Evidence Type
- Predictive
- Disease
- Multiple Myeloma
- Evidence Direction
- Supports
- Drug
- JQ-1
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21889194
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| JQ-1 | Sensitivity | true |