Annotation Detail

Information

Associated Genes: CD274
Associated Variants: CD274 EXPRESSION
CD274 EXPRESSION
Associated Disease: lung non-small cell carcinoma
Source Database: CIViC Evidence
Description: In this meta-analysis of 14 studies with 2857 patients, the immunotherapy response rate was higher among PD-L1-positive patients (RR: 2.19, 95% CI: 1.63-2.94). PD-L1 expression was also related to better progression-free survival (HR: 0.69, 95% CI: 0.57-0.85) and better overall survival (HR: 0.77, 95% CI: 0.67-0.89).
Variant Origin: N/A
Variant Origin: N/A
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/4857
Gene URL: https://civic.genome.wustl.edu/links/genes/11335
Variant URL: https://civic.genome.wustl.edu/links/variants/276
Rating: 4
Evidence Type: Predictive
Disease: Lung Non-small Cell Carcinoma
Evidence Direction: Supports
Drug: Durvalumab,Atezolizumab,Avelumab,Nivolumab,Pembrolizumab
Evidence Level: B
Clinical Significance: Sensitivity/Response
Pubmed: 28472902

Drugs