Annotation Detail

Information
Associated Genes
EGFR
Associated Variants
EGFR p.Cys797Tyr (p.C797Y) ( ENST00000275493.7, ENST00000450046.2, ENST00000455089.5 )
EGFR p.Cys797Tyr (p.C797Y) ( ENST00000275493.7, ENST00000450046.2, ENST00000455089.5 )
Associated Disease
malignant mesothelioma
Source Database
CIViC Evidence
Description
In an in vitro study, a COS-7 cell line expressing EGFR C797Y demonstrated increased sensitivity to erlotinib treatment, compared to COS-7 cells expressing EGFR wild-type. Sensitivity was determined by assessing EGFR auto-phosphorylation.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/4658
Gene URL
https://civic.genome.wustl.edu/links/genes/19
Variant URL
https://civic.genome.wustl.edu/links/variants/1574
Evidence Type
Predictive
Disease
Malignant Mesothelioma
Evidence Direction
Supports
Drug
Erlotinib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
20942962
Drugs
Drug NameSensitivitySupported
ErlotinibSensitivitytrue