Annotation Detail
Information
- Associated Genes
- EGFR
- Associated Variants
-
EGFR W731L
EGFR W731L - Associated Disease
- malignant mesothelioma
- Source Database
- CIViC Evidence
- Description
- In an in vitro study, a COS-7 cell line expressing EGFR W731L demonstrated increased sensitivity to erlotinib treatment, compared to COS-7 cells expressing EGFR wild-type. Sensitivity was determined by assessing EGFR auto-phosphorylation.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/4655
- Gene URL
- https://civic.genome.wustl.edu/links/genes/19
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1571
- Evidence Type
- Predictive
- Disease
- Malignant Mesothelioma
- Evidence Direction
- Supports
- Drug
- Erlotinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 20942962
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Erlotinib | Sensitivity | true |