Annotation Detail
Information
- Associated Genes
- PDGFRA
- Associated Variants
-
PDGFRA p.Ile843del (p.I843del), ENSG00000282278 p.Ile603del (p.I603del)
(
ENST00000257290.10 )
PDGFRA p.Ile843del (p.I843del), ENSG00000282278 p.Ile603del (p.I603del) ( ENST00000257290.10 ) - Associated Disease
- gastrointestinal stromal tumor
- Source Database
- CIViC Evidence
- Description
- In CHO cells with the PDGFRA deletion I843 mutation that have shown imatinib sensitivity, crenolanib showed no significant difference from imatinib in kinase activity inhibition.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/46
- Gene URL
- https://civic.genome.wustl.edu/links/genes/38
- Variant URL
- https://civic.genome.wustl.edu/links/variants/101
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Gastrointestinal Stromal Tumor
- Evidence Direction
- Supports
- Drug
- Crenolanib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 22745105
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Crenolanib | Sensitivity | true |