Annotation Detail
Information
- Associated Genes
- AURKA
- Associated Variants
-
AURKA OVEREXPRESSION
(
ENST00000395913.7 )
AURKA OVEREXPRESSION ( ENST00000395913.7 ) - Associated Disease
- cervical adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- In the cervial andenocarcinoma cell line HeLa, when AURK-A was overexpressed, the cells were resistant to the apoptotic effects of Taxol.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/457
- Gene URL
- https://civic.genome.wustl.edu/links/genes/61
- Variant URL
- https://civic.genome.wustl.edu/links/variants/181
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Cervical Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Paclitaxel
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 12559175
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | Resitance or Non-Reponse | true |