Annotation Detail
Information
- Associated Genes
- VHL
- Associated Variants
-
VHL LOSS-OF-FUNCTION
VHL LOSS-OF-FUNCTION - Associated Disease
- clear cell renal cell carcinoma
- Source Database
- CIViC Evidence
- Description
- In patients with renal clear cell carcinoma, patients with loss of function VHL mutations had shorter tumor-specific survival.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/428
- Gene URL
- https://civic.genome.wustl.edu/links/genes/58
- Variant URL
- https://civic.genome.wustl.edu/links/variants/159
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Clear Cell Renal Cell Carcinoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 11793370
Drugs