clear cell renal cell carcinoma (Cancer)

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Information
Disease name
clear cell renal cell carcinoma
Disease ID
DOID:4467
Description
"A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope." [url:http\://www.cancer.gov/dictionary?CdrID=45063, url:https\://cancergenome.nih.gov/cancersselected/kidneyclearcell]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT03284385 Active, not recruiting Phase 2 Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2 January 29, 2019 August 30, 2024
NCT01038778 Active, not recruiting Phase 1/Phase 2 Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer October 29, 2009 July 17, 2024
NCT02496208 Active, not recruiting Phase 1 Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors July 22, 2015 September 30, 2024
NCT02293980 Active, not recruiting Phase 1 A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001) November 25, 2014 November 30, 2026
NCT03829111 Active, not recruiting Phase 1 CBM588, Nivolumab, and Ipilimumab in Treating Patients With Stage IV or Advanced Kidney Cancer May 14, 2019 June 11, 2024
NCT03793166 Active, not recruiting Phase 3 Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study June 7, 2019 September 15, 2024
NCT01575548 Active, not recruiting Phase 3 Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Who Have No Evidence of Disease After Surgery August 8, 2012 February 22, 2025
NCT05663710 Active, not recruiting Phase 1/Phase 2 Phase 1b/2 Study of Combination 177Lu Girentuximab Plus Cabozantinib and Nivolumab in Treatment naïve Patients With Advanced Clear Cell RCC June 30, 2023 October 30, 2027
NCT05199272 Active, not recruiting Phase 1/Phase 2 A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies December 29, 2021 March 2025
NCT04022343 Active, not recruiting Phase 2 Neoadjuvant Cabozantinib in Treating Patients With Locally Advanced Kidney Cancer August 6, 2019 May 25, 2025
NCT04627064 Active, not recruiting Phase 1 ABEMA Alone or in COMBO With MK-6482 December 31, 2020 December 31, 2025
NCT03473730 Active, not recruiting Early Phase 1 Daratumumab in Treating Patients With Muscle Invasive Bladder Cancer or Metastatic Kidney Cancer May 29, 2018 June 30, 2024
NCT03308396 Active, not recruiting Phase 1/Phase 2 Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer December 19, 2017 December 2023
NCT02974738 Active, not recruiting Phase 1 A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001) December 7, 2016 April 14, 2025
NCT02210117 Active, not recruiting Early Phase 1 Nivolumab With or Without Bevacizumab or Ipilimumab Before Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed by Surgery November 25, 2014 November 30, 2025
NCT03092856 Active, not recruiting Phase 2 Axitinib With or Without Anti-OX40 Antibody PF-04518600 in Treating Patients With Metastatic Kidney Cancer July 19, 2017 July 19, 2025
NCT01684397 Active, not recruiting Phase 1/Phase 2 Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer November 21, 2012 January 2, 2025
NCT06090331 Available 89Zr-DFO-girentuximab Expanded Access Program (EAP)
NCT00602862 Completed N/A Effect of Sorafenib on ccRCC Uptake of Radiolabeled Bevacizumab or cG250 July 2007 June 2012
NCT00890747 Completed Phase 1 Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy August 2009
NCT05728515 Completed Early Phase 1 A Small-molecule Carbonic Anhydrase IX Targeting PET Tracer in Clear Cell Renal Cell Carcinoma December 25, 2021 March 4, 2022
NCT01141569 Completed Phase 2 A Study of RO4929097 in Patients With Advanced Renal Cell Carcinoma That Have Failed Vascular Endothelial Growth Factor (VEGF)/Vascular Endothelial Growth Factor Receptor (VEGFR) Therapy June 2010 December 2013
NCT01157091 Completed Phase 2 Pazopanib Hydrochloride in Treating Patients With Stage IV Kidney Cancer December 8, 2010 December 31, 2013
NCT01158222 Completed Phase 2 Sunitinib Malate in Treating Patients With Previously Untreated Metastatic Kidney Cancer August 18, 2010 February 1, 2017
NCT01158521 Completed Phase 2 Pazopanib Hydrochloride Before Surgery in Treating Patients With Kidney Cancer June 2010 January 2016
NCT01243359 Completed Phase 1 Sunitinib Malate and Bevacizumab in Treating Patients With Kidney Cancer or Advanced Solid Malignancies October 2010
NCT01497821 Completed Phase 1 AMG 172 First in Human Study in Patients With Kidney Cancer January 2012 January 2015
NCT05432947 Completed N/A 68Ga-P16-093 and 18F-FDG PET/CT Imaging in the Same Group of Clear Cell Renal Cell Carcinoma Patients April 14, 2022 September 15, 2022
NCT01727089 Completed Phase 2 Bevacizumab With or Without TRC105 in Treating Patients With Metastatic Kidney Cancer November 1, 2012 August 8, 2017
NCT04496089 Completed Phase 1 Evaluation of Safety, Biodistibution and Sensitivity/Specificity of PET/CT Imaging With 89Zr-TLX250 in Subjects With RCC August 1, 2020 April 6, 2021
NCT01826877 Completed Phase 1 Autologous Dendritic Cells in Treating Patients With Metastatic Kidney Cancer January 14, 2013 May 27, 2021
NCT01835158 Completed Phase 2 Cabozantinib-s-malate or Sunitinib Malate in Treating Patients With Previously Untreated Locally Advanced or Metastatic Kidney Cancer July 8, 2013
NCT04169711 Completed Phase 1 Study of ARO-HIF2 in Patients With Advanced Clear Cell Renal Cell Carcinoma August 17, 2020 July 22, 2022
NCT02118337 Completed Phase 1/Phase 2 A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies May 19, 2014 March 17, 2020
NCT02247583 Completed Investigating Patient Satisfaction With Oral Anti-Cancer Treatment February 2011 July 2013
NCT03849118 Completed Phase 3 89Zr-TLX250 for PET/CT Imaging of ccRCC- ZIRCON Study August 15, 2019 November 7, 2022
NCT02575222 Completed Phase 1 Study of Neoadjuvant Nivolumab in Patients With Non-metastatic Stage II-IV Clear Cell Renal Cell Carcinoma February 2016 June 9, 2020
NCT02607553 Completed Phase 2 Safety and Activity of G-202 in Patients With Clear Cell Renal Cell Carcinoma That Expresses PSMA June 2016 February 2017
NCT02626130 Completed Early Phase 1 Tremelimumab With or Without Cryoablation in Treating Patients With Metastatic Kidney Cancer March 30, 2016 June 20, 2022
NCT03680521 Completed Phase 2 Neoadjuvant Sitravatinib in Combination With Nivolumab in Patients With Clear Cell Renal Cell Carcinoma October 10, 2018 May 18, 2023
NCT02667886 Completed Phase 1/Phase 2 Trial of X4P-001 in Patients With Advanced Renal Cell Carcinoma January 2016 March 2022
NCT03163667 Completed Phase 2 CB-839 With Everolimus vs. Placebo With Everolimus in Participants With Renal Cell Carcinoma (RCC) September 6, 2017 June 1, 2020
NCT03015740 Completed Phase 1/Phase 2 Sitravatinib and Nivolumab in Treating Patients With Advanced or Metastatic Kidney Cancer April 23, 2017 September 6, 2022
NCT03108066 Completed Phase 2 PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma April 24, 2017 September 27, 2023
NCT02700568 Completed Phase 2 Axitinib in Metastatic Renal Cell Carcinoma Patients With Favorable Prognostic Factors January 2016 August 2018
NCT00027820 Completed Phase 1/Phase 2 Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer August 2001 September 5, 2004
NCT00078858 Completed Phase 1/Phase 2 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant September 2003
NCT00005799 Completed N/A Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer November 1999
NCT00101114 Completed Phase 2 Sorafenib and Interferon Alfa in Treating Patients With Metastatic or Unresectable Kidney Cancer September 2004
NCT00112840 Completed Phase 1/Phase 2 CCI-779 and Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney Cancer May 2005 September 10, 2015
NCT00126503 Completed Phase 1/Phase 2 Sorafenib Tosylate and Bevacizumab in Treating Patients With Advanced Kidney Cancer May 2005 February 2012
NCT00126594 Completed Phase 2 Sorafenib Tosylate With or Without Recombinant Interferon Alfa-2b in Treating Patients With Metastatic Kidney Cancer June 2005 August 2013
NCT00182702 Completed Phase 2 Ixabepilone in Treating Patients With Metastatic, Recurrent, or Unresectable Kidney Cancer July 2005
NCT00193258 Completed Phase 1/Phase 2 Bevacizumab, Erlotinib, and Imatinib in the Treatment of Advanced Renal Cell Carcinoma June 2004 August 2011
NCT00199888 Completed Phase 1 Safety Study With the Antibody, cG250, and Isotope, 124-Iodine, to Diagnose Patients With Renal Masses. June 2005 May 29, 2009
NCT05861778 Completed Phase 1 Evaluation of 89Zr-TLX250 PET/CT in Chinese Patients With Indeterminate Renal Masses or Suspected Recurrent Renal Clear Cell Carcinoma June 26, 2023 November 27, 2023
NCT00324870 Completed Phase 1/Phase 2 Vorinostat and Bevacizumab in Treating Patients With Unresectable or Metastatic Kidney Cancer February 2006 November 2013
NCT00326898 Completed Phase 3 Sunitinib Malate or Sorafenib Tosylate in Treating Patients With Kidney Cancer That Was Removed By Surgery April 24, 2006 September 1, 2021
NCT00335556 Completed Phase 2 Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors June 2006
NCT00378703 Completed Phase 2 Bevacizumab, Sorafenib Tosylate, and Temsirolimus in Treating Patients With Metastatic Kidney Cancer September 14, 2007 March 21, 2017
NCT00408902 Completed Phase 2 Tandutinib in Treating Patients Who Have Undergone Surgery for Metastatic Kidney Cancer November 2006 December 2008
NCT00499135 Completed Phase 1 Sunitinib Malate in Treating Patients With Unresectable or Metastatic Kidney Cancer or Other Advanced Solid Tumors May 22, 2007 May 14, 2014
NCT06447103 Not yet recruiting Phase 2 An Investigational Scan (89Zr-DFO-GmAb PET/CT) Compared to Contrast-Enhanced CT for the Detection of Recurrent Clear Cell Renal Cell Cancer After Surgery Comparing Carbonic Anhydrase IX (CAIX) PET CT to Conventional PET CT for Post-Op Staging in Kidney Cancer June 1, 2024 June 1, 2030
NCT04958473 Not yet recruiting Phase 2 A Study of Sintilimab in Combination With Axitinib in Advanced Renal Cell Cancer August 1, 2021 August 1, 2025
NCT05119335 Recruiting Phase 1/Phase 2 A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma October 26, 2021 September 2026
NCT06138496 Recruiting Phase 2 Cadonilimab Combination With Lenvatinib as Neoadjuvant Therapy for ccRCC September 1, 2023 December 31, 2025
NCT05214885 Recruiting Novel Biomarkers of Hypoxia and Metabolism in Clear Cell Renal Cell Carcinoma February 11, 2022 December 31, 2026
NCT05239533 Recruiting Phase 2 Study of Nivolumab in Combination With 177Lu-girentuximab for Kidney Cancer February 16, 2022 March 2025
NCT05286294 Recruiting Phase 2 Microbiota Transplant to Cancer Patients Who Have Failed Immunotherapy Using Faeces From Clinical Responders June 28, 2022 December 31, 2034
NCT05363631 Recruiting Phase 1/Phase 2 Seleno-L Methionine (SLM)-Axitinib-Pembrolizumab September 19, 2022 December 31, 2026
NCT04006405 Recruiting AURORAX-0087A: GAG Scores for Surveillance of Recurrence in Leibovich Points ≥5 Non-metastatic ccRCC January 10, 2020 February 2025
NCT05433142 Recruiting Phase 1 Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma June 13, 2022 March 2027
NCT05520099 Recruiting Observational Basket Trial to Collect Tissue to Train and Validate a Live Tumor Diagnostic Platform June 26, 2023 January 2027
NCT05536141 Recruiting Phase 1 A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors October 26, 2022 January 2026
NCT05620134 Recruiting Phase 1/Phase 2 Study of JK08 in Patients With Unresectable Locally Advanced or Metastatic Cancer October 17, 2022 February 20, 2026
NCT06088134 Recruiting Contrast-enhanced CT-based Deep Learning Model for Preoperative Prediction of Disease-free Survival (DFS) in Localized Clear Cell Renal Cell Carcinoma (ccRCC) September 1, 2022 August 1, 2024
NCT05879510 Recruiting Phase 2 68Ga-NY104 PET/CT for the Detection of Clear Cell Renal Cell Carcinoma in Presurgical Patients With Renal Masses August 1, 2023 July 1, 2025
NCT05795595 Recruiting Phase 1/Phase 2 A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors March 13, 2023 May 2030
NCT04053855 Recruiting Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma January 29, 2020 August 2024
NCT05879497 Recruiting Phase 2 68Ga-NY104 PET/CT in Patients With Metastasis/Recurrence Clear Cell Renal Cell Carcinoma Suspicion August 1, 2023 July 1, 2025
NCT04071223 Recruiting Phase 2 Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study July 29, 2020 October 1, 2024
NCT06242470 Recruiting Phase 1 A Study of MGC026 in Participants With Advanced Solid Tumors March 6, 2024 October 2028
NCT06339138 Recruiting Identification of Novel High Quality Methylated DNA Markers in Renal Tumors: Whole Methylome Discovery, Tissue Validation, and Feasibility Testing In Blood and Urine, The INQUIRE Study February 20, 2018 January 31, 2027
NCT04370509 Recruiting Phase 2 Pembrolizumab With or Without Axitinib for Treatment of Locally Advanced or Metastatic Clear Cell Kidney Cancer in Patients Undergoing Surgery February 9, 2021 September 1, 2025
NCT04374877 Recruiting Phase 1 Study of CHS-388 (Formerly Known as SRF388) in Patients With Advanced Solid Tumors April 22, 2020 August 2026
NCT06052852 Recruiting Phase 1/Phase 2 Study of BDC-3042 as Single Agent and in Combination With Pembrolizumab in Patients With Advanced Malignancies October 11, 2023 March 2028
NCT06049576 Recruiting Phase 1 Nivolumab and Ipilimumab With and Without Camu Camu for the Treatment of Patients With Metastatic Renal Cell Carcinoma October 6, 2023 March 14, 2026
NCT03682289 Recruiting Phase 2 Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors January 17, 2019 July 31, 2025
NCT04810078 Recruiting Phase 3 A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread May 24, 2021 January 29, 2026
NCT06195150 Recruiting Overtaking Intra and Inter Tumoral Heterogeneity In Von Hippel-Lindau Related Renal Cancer November 8, 2023 August 31, 2024
NCT04989959 Recruiting Phase 1 [18F]PT2385 PET/CT in Patients With Renal Cell Carcinoma August 18, 2021 August 18, 2026
NCT05935748 Recruiting Phase 2 Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc) July 28, 2023 September 2026
NCT05086692 Recruiting Phase 1/Phase 2 A Beta-only IL-2 ImmunoTherapY Study August 27, 2021 December 30, 2026
NCT04779151 Suspended Phase 2 Basket Trial Exploring the Efficacy and Safety of the Combination of Niraparib and Dostarlimab April 7, 2021 December 2027
NCT03185182 Terminated Phase 2 Diagnostic Imaging for Clear Cell Renal Cell Carcinoma July 14, 2017 September 12, 2018
NCT02923531 Terminated Phase 1/Phase 2 Addition of X4P-001 to Nivolumab Treatment in Participants With Renal Cell Carcinoma December 7, 2016 August 8, 2018
NCT03334409 Terminated Phase 2 Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery February 16, 2018 March 13, 2021
NCT02885649 Terminated Early Phase 1 Enzalutamide Before Surgery in Treating Patients With Kidney Cancer December 5, 2017 March 2, 2020
NCT02628535 Terminated Phase 1 Safety Study of MGD009 in B7-H3-expressing Tumors September 2015 November 25, 2019
NCT02595918 Terminated Phase 1 Nivolumab in Treating Patients With High-Risk Kidney Cancer Before Surgery May 19, 2016 August 1, 2020
NCT02581384 Terminated Phase 1/Phase 2 Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors January 2017 August 2020
NCT03875313 Terminated Phase 1/Phase 2 Study of CB-839 (Telaglenastat) in Combination With Talazoparib in Patients With Solid Tumors May 20, 2019 July 29, 2020
NCT01943188 Terminated Phase 1 Stereotactic Body Radiation Therapy and T-Cell Infusion in Treating Patients With Metastatic Kidney Cancer May 2014
NCT04300140 Terminated Phase 1/Phase 2 Safety and Efficacy Study of AVB-S6-500 (Batiraxcept) in Patients With Advanced or Metastatic Clear Cell Renal Cell Carcinoma February 26, 2021 August 14, 2023
NCT00098618 Terminated Phase 2 Sorafenib and Interferon Alfa in Treating Patients With Locally Advanced or Metastatic Kidney Cancer October 2004
NCT05121948 Terminated Phase 1 A Study of HC-7366 to Establish the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) February 23, 2022 March 1, 2024
NCT01599832 Terminated N/A Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Measuring Effects of Pazopanib Hydrochloride in Patients With Metastatic Kidney Cancer June 2012 December 2015
NCT01582009 Terminated Phase 1/Phase 2 Panobinostat and Everolimus in Treating Patients With Metastatic or Unresectable Renal Cell Cancer That Does Not Respond to Treatment With Sunitinib Malate or Sorafenib Tosylate March 2010 December 2015
NCT01198158 Terminated Phase 3 Everolimus With or Without Bevacizumab in Treating Patients With Advanced Kidney Cancer That Progressed After First-Line Therapy September 15, 2010 December 16, 2017
NCT00303862 Terminated Phase 2 AZD2171 in Treating Patients With Refractory Metastatic Kidney Cancer March 2006 March 2011
NCT00126659 Terminated Phase 2 Sorafenib in Treating Patients Who Are Undergoing Surgery for Metastatic Kidney Cancer January 2006 December 2009
NCT01069770 Unknown status Phase 2 Neoadjuvant Sunitinib Treatment for Metastatic Clear Cell Renal Cell Carcinoma (RCC) July 2009 June 2012
NCT03592199 Unknown status Phase 2 Biomarker Study of Pts With Metastatic ccRCC Undergoing Sequential Therapy With 1st Line Sunitinib and 2nd Line Axitinib December 11, 2017 December 11, 2022
NCT03438708 Unknown status Phase 2 Prior Axitinib as a Determinant of Outcome of Renal Surgery March 5, 2018 February 1, 2020
NCT04995016 Unknown status Phase 2 Pembrolizumab and Axitinib as Neoadjuvant Therapy for Locally Advanced Non-metastatic Clear Cell Renal Cell Carcinoma August 20, 2021 August 20, 2023
NCT01791387 Unknown status Phase 2 1st-line Activity of Dovitinib and Correlation With Genetic Changes in RCC March 2012 June 2015
NCT02022787 Unknown status Value of Various Chemokines in the Detection and Follow up of RCC January 2014 November 2016
NCT03987698 Unknown status Phase 2 Study of PD-1 Inhibitor Combination With Autologous Cell Immunotherapy in the Metastatic Renal Cell Carcinoma June 1, 2019 June 1, 2022
NCT01642095 Withdrawn Studying Biomarkers in Samples From Younger Patients With Kidney Cancer August 22, 2012
NCT03149159 Withdrawn Phase 2 Investigator-Initiated Trial of Combined Ipilimumab, Nivolumab and Stereotactic Radiation in Patients With Metastatic Clear-Cell RCC (ccRCC) Who Have Failed Treatment With Single-Agent Nivolumab April 1, 2018 April 1, 2018
NCT02307474 Withdrawn N/A A Pilot Study of SBRT With Adjuvant Pazopanib for Renal Cell Cancer September 2015 September 2015
Disase is a (Disease Ontology)
DOID:4450
Cross Reference ID (Disease Ontology)
GARD:9574
Cross Reference ID (Disease Ontology)
MESH:D002292
Cross Reference ID (Disease Ontology)
NCI:C4033
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:254915003
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0279702
Exact Synonym (Disease Ontology)
Clear cell carcinoma of kidney
Exact Synonym (Disease Ontology)
clear cell kidney carcinoma
Exact Synonym (Disease Ontology)
conventional (Clear cell) renal cell carcinoma
Exact Synonym (Disease Ontology)
conventional renal cell carcinoma
Exact Synonym (Disease Ontology)
renal clear cell carcinoma
Disase Synonym (Disease Ontology)
Clear-cell metastatic renal cell carcinoma
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0006770