Annotation Detail
Information
- Associated Genes
- KIT
- Associated Variants
-
KIT EXON 11 MUTATION
KIT EXON 11 MUTATION - Associated Disease
- gastrointestinal stromal tumor
- Source Database
- CIViC Evidence
- Description
- KIT mutation is associated with worse overall and cause-specific prognosis in patients with GIST compared to patients with wildtype KIT.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/376
- Gene URL
- https://civic.genome.wustl.edu/links/genes/29
- Variant URL
- https://civic.genome.wustl.edu/links/variants/66
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Gastrointestinal Stromal Tumor
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 10485475
Drugs