Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
-
MGMT PROMOTER METHYLATION
MGMT PROMOTER METHYLATION - Associated Disease
- glioblastoma
- Source Database
- CIViC Evidence
- Description
- In a randomized clinical trial, patients with MGMT promoter methyaltion benefitted from temozolomide. This benefit was also methylation status dependent, as those without methylation did not see increased survival.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/307
- Gene URL
- https://civic.genome.wustl.edu/links/genes/34
- Variant URL
- https://civic.genome.wustl.edu/links/variants/85
- Rating
- 5
- Evidence Type
- Predictive
- Disease
- Glioblastoma Multiforme
- Evidence Direction
- Supports
- Drug
- Temozolomide
- Evidence Level
- A
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 15758010
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Sensitivity | true |