Annotation Detail

Information
Associated Genes
MGMT
Associated Variants
MGMT UNDEREXPRESSION ( ENST00000306010.8 )
MGMT UNDEREXPRESSION ( ENST00000306010.8 )
Associated Disease
glioblastoma
Source Database
CIViC Evidence
Description
In 41 glioblastomas treated with temozolomide (TMZ) therapy (MGMT-immunopositive: n = 22, negative: n = 19), both progression free survival and overall survival were significantly better in MGMT-immunonegative glioblastomas. (PFS: P = 0.0015, OS: P = 0.0384).
Variant Origin
N/A
Variant Origin
N/A
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/2903
Gene URL
https://civic.genome.wustl.edu/links/genes/34
Variant URL
https://civic.genome.wustl.edu/links/variants/1255
Rating
3
Evidence Type
Predictive
Disease
Glioblastoma Multiforme
Evidence Direction
Supports
Drug
Temozolomide
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
21331613
Drugs
Drug NameSensitivitySupported
TemozolomideSensitivitytrue