Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 UNKNOWN
TP53 ALTERATION - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- In a group of patients with invasive ovarian carcinoma who had undergone surgery, a subset of 74 patients treated with platinum based chemotherapy were assessed for p53 alteration (p53 mutation or p53 overexpression by immunostaining >10% positive). Significant decreased time to progression (p=0.037) was seen in the subset of patients with p53 alteration (n=54) in comparison to the group with normatl p53 (n=20)
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/2771
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1307
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Drug
- Carboplatin,Cisplatin
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 11595686
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Carboplatin | Resitance or Non-Reponse | true |
| Cisplatin | Resitance or Non-Reponse | true |