Annotation Detail
Information
- Associated Genes
- KIT
- Associated Variants
-
KIT EXON 11 MUTATION
KIT EXON 11 MUTATION - Associated Disease
- gastrointestinal stromal tumor
- Source Database
- CIViC Evidence
- Description
- KIT mutation is associated with larger, more invasive tumors, greater pathologic histology and older patients compared to tumors with wildtype KIT.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/225
- Gene URL
- https://civic.genome.wustl.edu/links/genes/29
- Variant URL
- https://civic.genome.wustl.edu/links/variants/66
- Rating
- 2
- Evidence Type
- Diagnostic
- Disease
- Gastrointestinal Stromal Tumor
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Positive
- Pubmed
- 10485475
Drugs