Annotation Detail
Information
- Associated Genes
- NRAS
- Associated Variants
-
NRAS p.Gln61Leu (p.Q61L)
(
ENST00000369535.5 )
NRAS p.Gln61Leu (p.Q61L) ( ENST00000369535.5 ) - Associated Disease
- melanoma
- Source Database
- CIViC Evidence
- Description
- In a melanoma patient with NRAS Q61L mutation, treatment with temozolomide resulted in disease free survival of 14 months.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/22
- Gene URL
- https://civic.genome.wustl.edu/links/genes/36
- Variant URL
- https://civic.genome.wustl.edu/links/variants/95
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Melanoma
- Evidence Direction
- Supports
- Drug
- Temozolomide
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21576590
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Sensitivity | true |