Annotation Detail
Information
- Associated Genes
- NRAS
- Associated Variants
-
NRAS p.Gly13Asp (p.G13D)
(
ENST00000369535.5 )
NRAS p.Gly13Asp (p.G13D) ( ENST00000369535.5 ) - Associated Disease
- melanoma
- Source Database
- CIViC Evidence
- Description
- Likely due to increased reliance of mutant NRAS on HSP90 for stabilization, inhibition of HSP90 by 17-AAG was shown to be effective in a patient with metastatic malignant melanoma with an NRAS G13D mutation.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/21
- Gene URL
- https://civic.genome.wustl.edu/links/genes/36
- Variant URL
- https://civic.genome.wustl.edu/links/variants/93
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Melanoma
- Evidence Direction
- Supports
- Drug
- Tanespimycin
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 18375819
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Tanespimycin | Sensitivity | true |