Annotation Detail
Information
- Associated Genes
- CCNE1
- Associated Variants
-
CCNE1 AMPLIFICATION
(
ENST00000262643.8 )
CCNE1 AMPLIFICATION ( ENST00000262643.8 ) - Associated Disease
- ovarian serous cystadenocarcinoma
- Source Database
- CIViC Evidence
- Description
- A high throughput compound screen identified synergistic combinations in CCNE1 amplified high grade serous ovarian carcinoma, including dinaciclib and AKT inhibitors
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1735
- Gene URL
- https://civic.genome.wustl.edu/links/genes/11
- Variant URL
- https://civic.genome.wustl.edu/links/variants/187
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Ovarian Serous Cystadenocarcinoma
- Evidence Direction
- Supports
- Drug
- Dinaciclib,Akt Inhibitor MK2206
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 27663592
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Akt Inhibitor MK2206 | Sensitivity | true |
| Dinaciclib | Sensitivity | true |