Annotation Detail

Information
Associated Genes
CCND1
Associated Variants
CCND1 AMPLIFICATION ( ENST00000227507.3 )
CCND1 AMPLIFICATION ( ENST00000227507.3 )
Associated Disease
breast cancer
Source Database
CIViC Evidence
Description
A panel of 47 breast cancer cell lines was tested for sensitivty/resistance to CDK4/6 inhibitor Palbociclib (PD0332991), where IC50 below 150nM was sensitive, and above 1000nM resistant. Cyclin D1 had higher expression levels in sensitive cell lines.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1562
Gene URL
https://civic.genome.wustl.edu/links/genes/8
Variant URL
https://civic.genome.wustl.edu/links/variants/18
Rating
2
Evidence Type
Predictive
Disease
Breast Cancer
Evidence Direction
Supports
Drug
Palbociclib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
19874578
Drugs
Drug NameSensitivitySupported
PalbociclibSensitivitytrue