Annotation Detail

Information
Associated Genes
CCND1
Associated Variants
CCND1 OVEREXPRESSION ( ENST00000227507.3 )
CCND1 OVEREXPRESSION ( ENST00000227507.3 )
Associated Disease
mantle cell lymphoma
Source Database
CIViC Evidence
Description
A pharmacodynamic study (NCT00420056) of 17 mantle cell lymphoma MCL patients was performed using the CDK4/6 inhibitor palbociclib (PD0332991). Patients were verified by IHC, FISH or molecular testing for the t(11:14) rearrangement causing Cyclin D overexpression in MCL. 1 patient demonstrated complete response, and 2 showed partial response for an 18% overall response rate. 7 patients showed stable disease. Patient population was heavily pretreated.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1536
Gene URL
https://civic.genome.wustl.edu/links/genes/8
Variant URL
https://civic.genome.wustl.edu/links/variants/20
Rating
2
Evidence Type
Predictive
Disease
Mantle Cell Lymphoma
Evidence Direction
Does Not Support
Drug
Palbociclib
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
22383795
Drugs
Drug NameSensitivitySupported
PalbociclibSensitivityfalse