Annotation Detail

Information

Associated Genes: CD274
Associated Variants: CD274 EXPRESSION
CD274 EXPRESSION
Associated Disease: lung non-small cell carcinoma
Source Database: CIViC Evidence
Description: Meta-Analysis of PD-L1 (CD274) Expression Status in 914 patients (7 studies) and response to PD-1/PD-L1 monoclonal antibodies. Patients with PD-L1 positive tumors (PD-L1 tumor cell staining ≥1%), had a significantly higher ORR, compared to patients with PD-L1 negative tumors (OR: 2.44; 95% CIs: 1.61-3.68).
Variant Origin: N/A
Variant Origin: N/A
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/1167
Gene URL: https://civic.genome.wustl.edu/links/genes/11335
Variant URL: https://civic.genome.wustl.edu/links/variants/276
Rating: 4
Evidence Type: Predictive
Disease: Lung Non-small Cell Carcinoma
Evidence Direction: Supports
Drug: Atezolizumab,Nivolumab,Avelumab,Pembrolizumab
Evidence Level: B
Clinical Significance: Sensitivity/Response
Pubmed: 26918451

Drugs