DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

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Information
Clinical Significance
Ranking
Frequency
Disease area statistics
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Information

Symbol: DIS3
Type: protein-coding
Description: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Entrez Gene ID: 22894
Genome: hg19
Position: chr13:73,326,307-73,356,038
Genome: hg38
Position: chr13:72,752,169-72,781,900
MIM: 607533 OMIM
HGNC: HGNC:20604 HGNC
Ensembl: ENSG00000083520 Ensembl
Links: NCBI Gene Cards OncoKB

Clinical Significance

	MGeND	ClinVar
Likely pathogenic	0	2
Benign	0	8
Likely benign	0	12
not provided	16	0
Uncertain significance	0	94

Ranking

	ClinVar
	0
	0
	2
	108
	4

Frequency

EXAC_EAS

EXAC_EAS

HGVD

HGVD

TOMMO

TOMMO

Gene

Position

EXAC_EAS

EXAC_EAS

HGVD

HGVD

TOMMO

TOMMO

Gene

Position

Disease area statistics

Locus Zoom

Variants

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Target data	:	MGeND data only
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Variant name	Gene	AA change	CDS	Japanese frequency	TogoVar	MGeND				Genome	ClinVar			CIViC evidence	DisGeNET entry	COSMIC occurrence	Prediction
Variant name	Gene	AA change	CDS	Japanese frequency	TogoVar	Entry	Origin	Type	Annotation	Genome	Entry	Origin	Annotation	CIViC evidence	DisGeNET entry	COSMIC occurrence	Prediction

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Name	MGeND				Type	Genome	Size	Chromosome	Start	Stop	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry
Name	Entry	Origin	Type	Annotation	Type	Genome	Size	Chromosome	Start	Stop	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry

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Target data	:	MGeND data only
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Name	MGeND				Type	Genome	Gene symbol	Chromosome	Genomic start	Genomic stop	Strand	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry
Name	Entry	Origin	Type	Annotation	Type	Genome	Gene symbol	Chromosome	Genomic start	Genomic stop	Strand	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry

Type	ID
SYNONYM	2810028N01Rik
SYNONYM	EXOSC11
SYNONYM	KIAA1008
SYNONYM	RRP44
SYNONYM	dis3p
MIM	607533 OMIM
HGNC	HGNC:20604 HGNC
Ensembl	ENSG00000083520 Ensembl
AllianceGenome	HGNC:20604

Descrption	Source	Links

ID	Genome	Chromosome	Start	End	Length
ENST00000545453.5	hg38	chr13	72,759,044	72,782,096	23,053
ENST00000377767.9	hg38	chr13	72,752,169	72,781,900	29,732
ENST00000377780.8	hg38	chr13	72,757,443	72,781,925	24,483
ENST00000377767.9	hg19	chr13	73,326,307	73,356,038	29,732
ENST00000377780.8	hg19	chr13	73,331,581	73,356,063	24,483
ENST00000545453.5	hg19	chr13	73,333,182	73,356,234	23,053

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