TAE684

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Information
Drug Name
TAE684
Description
Entry(CIViC)
10
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
lung non-small cell carcinoma ALK EML4-ALK E6;A20 D Predictive Supports Sensitivity/Response Somatic 2 18451166 Detail
lung non-small cell carcinoma ALK EML4-ALK E6;A20 D Predictive Does Not Support Sensitivity/Response Somatic 2 18594010 Detail
lung non-small cell carcinoma ROS1 CD74-ROS1 L2155S D Predictive Supports Resistance Somatic 3 25688157 Detail
diffuse large B-cell lymphoma ALK CLTC-ALK D Predictive Supports Sensitivity/Response Somatic 4 21494621 Detail
lung non-small cell carcinoma ALK p.Ile1171Thr (p.I1171T) ALK p.Ile1171Thr (p.I1171T) D Predictive Supports Sensitivity/Response Somatic 3 25228534 Detail
lung non-small cell carcinoma ALK EML4-ALK V1180L D Predictive Supports Sensitivity/Response Somatic 3 25228534 Detail
lung non-small cell carcinoma ALK EML4-ALK T1151INST D Predictive Supports Resistance Somatic 3 22277784 Detail
neuroblastoma ALK p.Phe1174Leu (p.F1174L)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) ALK p.Phe1174Leu (p.F1174L)
( ENST00000618119.4, ENST00000642122.1, ENST00000389048.8 ) 		D Predictive Supports Sensitivity/Response Somatic 4 18923525 Detail
neuroblastoma ALK p.Arg1275Gln (p.R1275Q)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) ALK p.Arg1275Gln (p.R1275Q)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) 		D Predictive Supports Sensitivity/Response Somatic 3 18923525 Detail
neuroblastoma ALK p.Arg1275Gln (p.R1275Q)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) ALK p.Arg1275Gln (p.R1275Q)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) 		D Predictive Supports Resistance Somatic 3 18923525 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
In a panel of 602 cancer cell lines, 3/134 NSCLC c... ALK ALK EML4-ALK E6;A20 Sensitivity true CIViC Evidence detail
Exon-array and RT-PCR was used to screen a panel o... ALK ALK EML4-ALK E6;A20 Sensitivity false CIViC Evidence detail
The L2155S mutation in ROS1 was identified in the ... ROS1 ROS1 CD74-ROS1 L2155S Resitance or Non-Reponse true CIViC Evidence detail
A cell line called LM1 was established from the bo... ALK ALK CLTC-ALK Sensitivity true CIViC Evidence detail
The I1171T ALK kinase domain mutaion was found in ... ALK ALK p.Ile1171Thr (p.I1171T) ALK p.Ile1171Thr (p.I1171T) Sensitivity true CIViC Evidence detail
The V1180L mutation in the kinase domain of rearra... ALK ALK EML4-ALK V1180L Sensitivity true CIViC Evidence detail
Treatment of Ba/F3 cells expressing EML4-ALK 1151 ... ALK ALK EML4-ALK T1151INST Resitance or Non-Reponse true CIViC Evidence detail
SH-SY5Y and Kelly cells with mutant ALK (F1174L) a... ALK ALK p.Phe1174Leu (p.F1174L)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) ALK p.Phe1174Leu (p.F1174L)
( ENST00000618119.4, ENST00000642122.1, ENST00000389048.8 ) 		Sensitivity true CIViC Evidence detail
TAE684 inhibits growth of Ba/F3 cells expressing A... ALK ALK p.Arg1275Gln (p.R1275Q)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) ALK p.Arg1275Gln (p.R1275Q)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) 		Sensitivity true CIViC Evidence detail
The SMS-KCNR cell line harboring the R1275Q mutati... ALK ALK p.Arg1275Gln (p.R1275Q)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) ALK p.Arg1275Gln (p.R1275Q)
( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) 		Resitance or Non-Reponse true CIViC Evidence detail