NSC348884

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Information
Drug Name
NSC348884
Description
Entry(CIViC)
2
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
acute myeloid leukemia NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION D Predictive Supports Sensitivity/Response Somatic 3 21719597 Detail
acute myeloid leukemia NPM1 p.Trp288CysfsTer12 (p.W288Cfs*12)
( ENST00000296930.10, ENST00000351986.10, ENST00000517671.5, ENST00000521672.6, ENST00000676589.1, ENST00000677297.1, ENST00000677325.1, ENST00000677357.1, ENST00000677907.1, ENST00000679190.1 ) NPM1 p.Trp288CysfsTer12 (p.W288Cfs*12)
( ENST00000679190.1, ENST00000677357.1, ENST00000296930.10, ENST00000351986.10, ENST00000517671.5, ENST00000521672.6, ENST00000676589.1, ENST00000677297.1, ENST00000677325.1, ENST00000677907.1 ) 		D Predictive Supports Sensitivity/Response Somatic 3 21719597 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
NSC348884 combined with ATRA treatment induces apo... NPM1 NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION Sensitivity true CIViC Evidence detail
NSC348884 induced apoptosis in OPI-AML3 cells harb... NPM1 NPM1 p.Trp288CysfsTer12 (p.W288Cfs*12)
( ENST00000296930.10, ENST00000351986.10, ENST00000517671.5, ENST00000521672.6, ENST00000676589.1, ENST00000677297.1, ENST00000677325.1, ENST00000677357.1, ENST00000677907.1, ENST00000679190.1 ) NPM1 p.Trp288CysfsTer12 (p.W288Cfs*12)
( ENST00000679190.1, ENST00000677357.1, ENST00000296930.10, ENST00000351986.10, ENST00000517671.5, ENST00000521672.6, ENST00000676589.1, ENST00000677297.1, ENST00000677325.1, ENST00000677907.1 ) 		Sensitivity true CIViC Evidence detail