Lomustine
Information
- Drug Name
- Lomustine
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| malignant astrocytoma |
ATRX UNDEREXPRESSION ( ENST00000373344.11 ) ATRX UNDEREXPRESSION ( ENST00000373344.11 ) |
B |
Predictive
|
Supports
|
N/A
|
3 | 23904111 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| A retrospective tumor sample study found that the ... | ATRX |
ATRX UNDEREXPRESSION ( ENST00000373344.11 ) ATRX UNDEREXPRESSION ( ENST00000373344.11 ) |
N/A | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03678883 | Active, not recruiting | Phase 2 | 9-ING-41 in Patients With Advanced Cancers | January 4, 2019 | November 2025 |
| NCT02724579 | Active, not recruiting | Phase 2 | Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma | November 17, 2017 | June 30, 2027 |
| NCT04762069 | Active, not recruiting | Phase 2 | A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme | May 18, 2021 | March 2025 |
| NCT01582269 | Active, not recruiting | Phase 2 | A Study in Recurrent Glioblastoma (GB) | April 26, 2012 | September 2024 |
| NCT00085735 | Active, not recruiting | Phase 3 | Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma | April 2004 | |
| NCT01682187 | Active, not recruiting | Phase 1 | A Dose-Escalation Study in Participants With Recurrent Malignant Glioma | December 15, 2005 | September 30, 2024 |
| NCT00003114 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With AIDS-Related Hodgkin's Disease | July 1997 | February 2003 |
| NCT00003375 | Completed | Phase 2/Phase 3 | Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma | October 1998 | May 14, 2018 |
| NCT00002569 | Completed | Phase 3 | Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma | July 1994 | May 21, 2018 |
| NCT00005796 | Completed | Phase 1 | Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors | February 2000 | December 2011 |
| NCT00006024 | Completed | Phase 1 | Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma | November 2000 | September 2006 |
| NCT00049439 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin's Lymphoma | March 1998 | February 2008 |
| NCT00052455 | Completed | Phase 3 | Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma | October 2002 | September 2010 |
| NCT00058370 | Completed | N/A | Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma | February 2003 | June 2019 |
| NCT00072345 | Completed | Phase 2 | Temozolomide, Thalidomide, and Lomustine in Treating Patients With Unresectable Stage III or Stage IV Melanoma | July 2003 | |
| NCT00074191 | Completed | Phase 2 | Methotrexate, Procarbazine, Lomustine, Dexamethasone, and Cytarabine in Treating Patients With Primary CNS Lymphoma | January 2000 | October 2000 |
| NCT00100802 | Completed | Phase 2 | Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas | March 21, 2005 | June 30, 2017 |
| NCT03425292 | Completed | Phase 1 | A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer | March 1, 2018 | October 27, 2023 |
| NCT02926222 | Completed | Phase 2 | Regorafenib in Relapsed Glioblastoma | November 2015 | June 2021 |
| NCT02843230 | Completed | Monitoring Anti-angiogenic Therapy in Brain Tumors by Advanced MRI | August 1, 2016 | January 31, 2022 | |
| NCT00293280 | Completed | Phase 2 | Lomustine in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer | July 2005 | |
| NCT00295815 | Completed | Phase 3 | Enzastaurin Versus Lomustine in Glioblastoma | January 2006 | May 2014 |
| NCT00303810 | Completed | N/A | Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma | January 2001 | |
| NCT01934361 | Completed | Phase 1 | Phase Ib/II Study of Buparlisib Plus Carboplatin or Lomustine in Patients With Recurrent Glioblastoma Multiforme | February 28, 2014 | July 7, 2016 |
| NCT00002806 | Completed | Phase 2 | Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial Glioma | July 1996 | July 2004 |
| NCT00002840 | Completed | Phase 3 | Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma | August 1996 | |
| NCT00002875 | Completed | Phase 3 | Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma | December 1996 | January 2011 |
| NCT00002944 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Progressive Brain Tumors | April 1997 | April 2012 |
| NCT00003101 | Completed | Phase 2 | Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With Oligodendroglioma | August 1997 | January 2002 |
| NCT01067469 | Completed | Phase 2 | Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM) | January 2010 | October 2016 |
| NCT01290939 | Completed | Phase 3 | Bevacizumab and Lomustine for Recurrent GBM | October 2011 | April 2020 |
| NCT01775475 | Completed | Phase 2 | Intravenous Chemotherapy or Oral Chemotherapy in Treating Patients With Previously Untreated Stage III-IV HIV-Associated Non-Hodgkin Lymphoma | September 15, 2016 | July 15, 2021 |
| NCT00503204 | Completed | Phase 1 | Phase I : Cediranib in Combination With Lomustine Chemotherapy in Recurrent Malignant Brain Tumour | September 2007 | December 2008 |
| NCT00504660 | Completed | Phase 2 | 6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients | September 2003 | August 2010 |
| NCT00527657 | Completed | Phase 1 | Temozolomide, Thalidomide, and Lomustine (TTL) in Melanoma Patients | February 9, 2006 | February 2, 2012 |
| NCT00590837 | Completed | Phase 3 | Adding Lomustine to Chemotherapy in Older Patients With Acute Myelogenous Leukemia (AML), and Allogeneic Transplantation for Patients From 60 to 65 Years Old | February 2008 | December 2013 |
| NCT02343406 | Completed | Phase 2 | Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas | February 17, 2015 | June 24, 2019 |
| NCT01860638 | Completed | Phase 2 | A Comparison of Continuous Bevacizumab (Avastin) Treatment or Placebo in Addition to Lomustine Followed by Standard of Care After Disease Progression in Participants With Glioblastoma | August 19, 2013 | May 5, 2017 |
| NCT06325683 | Not yet recruiting | Phase 2 | Anti-Lag-3 (Relatlinib) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma | August 16, 2024 | July 15, 2028 |
| NCT06419946 | Not yet recruiting | Phase 3 | Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma | May 15, 2024 | December 15, 2031 |
| NCT06336291 | Not yet recruiting | Phase 2 | A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or Recurrence | June 2024 | June 2026 |
| NCT05095376 | Recruiting | Phase 3 | Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma | November 29, 2021 | August 8, 2031 |
| NCT03382977 | Recruiting | Phase 1/Phase 2 | Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM Subjects | December 6, 2017 | August 2025 |
| NCT03970447 | Recruiting | Phase 2/Phase 3 | A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma | July 30, 2019 | June 2028 |
| NCT04049669 | Recruiting | Phase 2 | Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG | October 2, 2019 | October 2, 2027 |
| NCT04402073 | Recruiting | Phase 2 | Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma | November 11, 2022 | March 1, 2030 |
| NCT04573192 | Recruiting | Phase 1/Phase 2 | A Study to Evaluate Safety and Efficacy of L19TNF Plus Lomustine in Patients With Glioblastoma at First Progression | February 19, 2021 | December 2025 |
| NCT04863950 | Recruiting | Phase 2 | Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent Glioblastoma | May 25, 2022 | September 2025 |
| NCT05902169 | Recruiting | Phase 3 | Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM | January 29, 2024 | June 30, 2028 |
| NCT05904119 | Recruiting | Phase 3 | Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study | March 15, 2024 | February 2028 |
| NCT06283927 | Recruiting | The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302) | January 1, 2023 | January 1, 2028 | |
| NCT05382338 | Suspended | Phase 3 | A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss | February 20, 2023 | December 20, 2027 |
| NCT02765165 | Terminated | Phase 1/Phase 2 | Phase 1/2 Study of USL311 +/- Lomustine in Advanced Solid Tumors or Relapsed/Recurrent Glioblastoma Multiforme (GBM) | April 2016 | July 1, 2020 |
| NCT03022578 | Terminated | Phase 2 | Laser Interstitial Thermal Therapy and Lomustine in Treating Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma | November 7, 2017 | February 16, 2021 |
| NCT00031590 | Terminated | Phase 2 | Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly Diagnosed Medulloblastoma | April 2001 | May 2011 |
| NCT00003113 | Terminated | Phase 2 | Oral Combination Chemotherapy in Treating Elderly Patients With Intermediate or High-Grade Non-Hodgkin's Lymphomas | July 1997 | December 2002 |
| NCT01563614 | Terminated | Phase 1 | A Clinical Trial to Assess the Safety & Efficacy of the Treatment of Patients With Metastasis From Malignant Melanoma - Treatment Consists of the Substances Lomustine (Capsules) & Cytarabine (Injected Into an Area Near the Spinal Cord), Accompanied by Radiotherapy of the Brain | March 2012 | November 2015 |
| NCT00948389 | Terminated | Phase 1/Phase 2 | Study of CCNU (Lomustine) Plus Dasatinib in Recurrent Glioblastoma (GBM) | October 2009 | May 2011 |
| NCT01989052 | Terminated | Phase 1 | Ph 1/2 CTO With Lomustine for Bevacizumab-Naive Recurrent Glioma | May 2014 | February 2016 |
| NCT02212574 | Terminated | Early Phase 1 | Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblastoma | April 4, 2017 | November 9, 2018 |
| NCT00761280 | Terminated | Phase 3 | Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma | December 2008 | June 2012 |
| NCT02414165 | Terminated | Phase 2/Phase 3 | The Toca 5 Trial: Toca 511 & Toca FC Versus Standard of Care in Patients With Recurrent High Grade Glioma | November 30, 2015 | December 20, 2019 |
| NCT00003788 | Unknown status | Phase 3 | Surgery, Radiation Therapy, and Chemotherapy With or Without Photodynamic Therapy in Treating Patients With Newly Diagnosed or Recurrent Malignant Supratentorial Gliomas | April 1998 | |
| NCT00003603 | Unknown status | Phase 3 | Chemotherapy Plus Steroid Therapy in Treating Patients With Multiple Myeloma | March 1998 | |
| NCT00989352 | Unknown status | Phase 2 | Methotrexate-based Chemo-immunotherapy Followed by Maintenance Therapy for Patients > 65 Years With Central Nervous System (CNS)-Lymphoma | September 2009 | September 2011 |
| NCT02796261 | Unknown status | Phase 3 | Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients | July 2016 | June 2023 |
| NCT03025893 | Unknown status | Phase 2/Phase 3 | A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme | August 31, 2018 | January 1, 2022 |
| NCT00274911 | Unknown status | Phase 2 | Radiation Therapy Followed By Combination Chemotherapy in Treating Young Patients With Supratentorial Primitive Neuroectodermal Tumors | February 2004 | |
| NCT00053872 | Unknown status | Phase 3 | Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma | February 2003 | |
| NCT03758014 | Unknown status | Phase 2/Phase 3 | Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients | November 27, 2018 | April 30, 2021 |
| NCT00278278 | Unknown status | Phase 3 | Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas | September 2003 | |
| NCT00276666 | Unknown status | Phase 2 | Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Metastatic Medulloblastoma Who Have Undergone Surgery | November 2001 | |
| NCT00317408 | Unknown status | N/A | Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma | April 2004 | |
| NCT04933942 | Withdrawn | Phase 2 | Phase II Trial of Romiplostim for Thrombocytopenia Induced by Lomustine at First Progression of MGMT Promoter-meth Glioblastoma | September 13, 2022 | December 19, 2022 |
| NCT05017610 | Withdrawn | Early Phase 1 | Inducing a Hypothyroxinemic State in Patients With Recurrent Glioblastoma or Gliosarcoma | October 20, 2021 | October 14, 2022 |
| NCT00003929 | Withdrawn | Phase 2 | Chemotherapy, Filgrastim, and Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma | June 1998 | |
| NCT05410301 | Withdrawn | N/A | Golden Halo, Static Magnetic and Electric Field Device, in Recurrent Glioblastoma | April 2023 | August 2026 |
| NCT05304663 | Withdrawn | Phase 1 | Safety and Efficacy of Different Administration Sequences of L19TNF With Lomustine in Glioblastoma at First Progression | June 1, 2022 | December 31, 2024 |