Lometrexol
Information
- Drug Name
- Lometrexol
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| childhood B-cell acute lymphoblastic leukemia | PRPS1 A190V PRPS1 A190V | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 25962120 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Treatment with the GART inhibitor, Lometrexol (de ... | PRPS1 | PRPS1 A190V PRPS1 A190V | Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00024310 | Unknown status | Phase 1 | Paclitaxel, Folic Acid, and Lometrexol in Treating Patients With Locally Advanced or Metastatic Solid Tumors | September 2001 | |
| NCT00033722 | Unknown status | Phase 2 | Lometrexol Plus Folic Acid in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer | February 2002 |