GSK126
Information
- Drug Name
- GSK126
- Description
- Entry(CIViC)
- 2
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| skin melanoma | EZH2 Y646 EZH2 Y646 | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 26304929 | Detail |
| ovarian clear cell carcinoma | ARID1A MUTATION ARID1A MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 25686104 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Preclinical study in melanoma cell lines. EZH2 exp... | EZH2 | EZH2 Y646 EZH2 Y646 | Sensitivity | true | CIViC Evidence | detail |
| Inhibition of the EZH2 methyltransferase acts in a... | ARID1A | ARID1A MUTATION ARID1A MUTATION | Sensitivity | true | CIViC Evidence | detail |